Toward Community-Driven Big Open Brain Science: Open Big Data and Tools for Structure, Function, and Genetics

As acquiring bigger data becomes easier in experimental brain science, com-putational and statistical brain science must achieve similar advances to fullycapitalize on these data. Tackling these problems will benefit from a moreexplicit and concerted effort to work together. Specifically, brain sciencecan be further democratized by harnessing the power of community-driven tools, which both are built by and benefit from many different people with different backgroundsand expertise. This perspective can be applied across modalities and scales and enables collabora-tions across previously siloed communities.

Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.