Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.

D. Tward, T. Brown, Y. Kageyama, J. Patel, Z. Hou, S. Mori, M. Albert, J. Troncoso, and M. Miller, in Frontiers in neuroscience.
Quantification OF 3D tangle distribution in medial temporal lobe using multimodal image registration and convolutional neural networks
D. J. Tward, T. Brown, J. Patel, Y. Kageyama, S. Mori, J. C. Troncoso, and M. Miller, in Alzheimer's \& Dementia: The Journal of the Alzheimer's Association.