3D printing hippocampi to depict atrophy-related Alzheimer's biomarkers

This work discusses the challenges of 3D printing hippocampi from annotated post mortem MRI. This work will help visualize subtle changes to complex anatomy during the disease.

F. Xu, E. Xu, J. Troncoso, M. Albert, D. J. Tward, and M. Miller, in Proceedings of the 2020 Summer Biomechanics, Bioengineering, and Biotransport Conference.
Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.

D. Tward, T. Brown, Y. Kageyama, J. Patel, Z. Hou, S. Mori, M. Albert, J. Troncoso, and M. Miller, in Frontiers in neuroscience.
Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment
S. Kulason, D. J. Tward, T. Brown, C. S. Sicat, C. Liu, J. T. Ratnanather, L. Younes, A. Bakker, M. Gallagher, M. Albert, and others, in NeuroImage: Clinical.
Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry
D. J. Tward, C. S. Sicat, T. Brown, A. Bakker, M. Gallagher, M. Albert, M. Miller, Alzheimer's Disease Neuroimaging Initiative, and others, in Alzheimer's \& Dementia: Diagnosis, Assessment \& Disease Monitoring.
Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort
M. I. Miller, L. Younes, J. T. Ratnanather, T. Brown, H. Trinh, D. S. Lee, D. Tward, P. B. Mahon, S. Mori, M. Albert, and others, in Neurobiology of aging.