Entorhinal and transentorhinal atrophy in preclinical Alzheimer's disease

This work discusses atrophy in the medial temporal lobe during the progression of early Alzheimer's disease.

S. Kulason, E. Xu, D. J. Tward, M. S. Albert, L. Younes, and M. I. Miller, in Frontiers in Neuroscience.
Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.

D. Tward, T. Brown, Y. Kageyama, J. Patel, Z. Hou, S. Mori, M. Albert, J. Troncoso, and M. Miller, in Frontiers in neuroscience.
On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale
D. J. Tward, and M. I. Miller, in Frontiers in neuroscience.