Early amygdala and erc atrophy linked to 3d reconstruction of rostral neurofibrillary tau tangle pathology in alzheimer's disease

Studying shape changes in the amygdala and relating them to tau tangles detected in digital pathology.

K. M. Stouffer, C. Chen, S. Kulason, E. Xu, M. P. Witter, C. Ceritoglu, M. S. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller, and {for the Alzheimer's Neuroimaging Initiative}, in NeuroImage: Clinical.
3D printing hippocampi to depict atrophy-related Alzheimer's biomarkers

This work discusses the challenges of 3D printing hippocampi from annotated post mortem MRI. This work will help visualize subtle changes to complex anatomy during the disease.

F. Xu, E. Xu, J. Troncoso, M. Albert, D. J. Tward, and M. Miller, in Proceedings of the 2020 Summer Biomechanics, Bioengineering, and Biotransport Conference.
Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.

D. Tward, T. Brown, Y. Kageyama, J. Patel, Z. Hou, S. Mori, M. Albert, J. Troncoso, and M. Miller, in Frontiers in neuroscience.
Expanding the Computational Anatomy Gateway from clinical imaging to basic neuroscience research
D. Tward, A. Kolasny, F. Khan, J. Troncoso, and M. Miller, in Proceedings of the Practice and Experience in Advanced Research Computing on Rise of the Machines (learning).