Early amygdala and erc atrophy linked to 3d reconstruction of rostral neurofibrillary tau tangle pathology in alzheimer's disease

Studying shape changes in the amygdala and relating them to tau tangles detected in digital pathology.
Hidden Markov modeling for maximum probability neuron reconstruction

We developed a new technique for automatically tracing out long neuron processes in microscopy images.
Projective diffeomorphic mapping of molecular digital pathology with tissue MRI

We formalized mathematical techniques for joint 3D reconstruction of digital pathology with MRI.
Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry

We developed a new approach to studying the geometry of axons using data from the MouseLight project.
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

We quantified a new fluorescence technique that labels all AMPA receptors int he mouse brain.
Multi Scale Diffeomorphic Metric Mapping of Spatial Transcriptomics Datasets

We develpoed a novel approach for summarizing imaging features at different scales, and computing distances between images represented in this manner.
From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data

Our analysis of tau tangles and amyloid plaques, using the windowed scattering transform to extract informative features from microscopy images. Presented at the MICCAI conference.
Quantifying Patterns of Pathology: A Characterization of the 3D Spatial Distribution of Tau Tangles and Amyloid Plaques in Alzheimer's Disease Using Multi-Modal Image Registration with a Scattering Transform
A poster at the Alzheimer's association international conference desribing our analysis of tau tangles and amyloid plaques detected and reconstructed in 3D.
Entorhinal and transentorhinal atrophy in preclinical Alzheimer's disease

This work discusses atrophy in the medial temporal lobe during the progression of early Alzheimer's disease.
infinitesimal drift diffeomorphometry models for population shape analysis

This work discusses time dependent models of shape changes to study neurodegeneration.