Early amygdala and erc atrophy linked to 3d reconstruction of rostral neurofibrillary tau tangle pathology in alzheimer's disease

Studying shape changes in the amygdala and relating them to tau tangles detected in digital pathology.

K. M. Stouffer, C. Chen, S. Kulason, E. Xu, M. P. Witter, C. Ceritoglu, M. S. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller, and {for the Alzheimer's Neuroimaging Initiative}, in NeuroImage: Clinical.
Quantifying Patterns of Pathology: A Characterization of the 3D Spatial Distribution of Tau Tangles and Amyloid Plaques in Alzheimer's Disease Using Multi-Modal Image Registration with a Scattering Transform

A poster at the Alzheimer's association international conference desribing our analysis of tau tangles and amyloid plaques detected and reconstructed in 3D.

K. M. Stouffer, Z. Wang, E. Xu, K. S. Lee, P. Lee, S. Mori, J. C. Troncoso, A. Saito, M. S. Albert, M. I. Miller, and D. J. Tward, in 2021 Alzheimer's Association International Conference.
Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

We develop methods for accurate image registration between images of different modalities, possibly in the presence of damaged or missing tissue. We use this approach to build the first 3D reconstruction of tau tangle pathology in the medial temporal lobe for an individual who died of Alzheimer's disease.

D. Tward, T. Brown, Y. Kageyama, J. Patel, Z. Hou, S. Mori, M. Albert, J. Troncoso, and M. Miller, in Frontiers in neuroscience.
Quantification OF 3D tangle distribution in medial temporal lobe using multimodal image registration and convolutional neural networks
D. J. Tward, T. Brown, J. Patel, Y. Kageyama, S. Mori, J. C. Troncoso, and M. Miller, in Alzheimer's \& Dementia: The Journal of the Alzheimer's Association.
Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort
M. I. Miller, L. Younes, J. T. Ratnanather, T. Brown, H. Trinh, D. S. Lee, D. Tward, P. B. Mahon, S. Mori, M. Albert, and others, in Neurobiology of aging.
Bayesian multiple atlas deformable templates
M. Miller, S. Mori, X. Tang, D. Tward, and Y. Zhang, in Acquisition Methods, Methods and Modeling.
Network neurodegeneration in Alzheimer’s disease via MRI based shape diffeomorphometry and high-field atlasing
M. I. Miller, J. T. Ratnanather, D. J. Tward, T. Brown, D. S. Lee, M. Ketcha, K. Mori, M. Wang, S. Mori, M. S. Albert, and others, in Frontiers in bioengineering and biotechnology.