Visualization of Speech Perception Analysis via Phoneme Alignment: A Pilot Study

We developed a tool to align heard and spoken words, at the level of phonemes, for quantifying speech perception errors in people with hearing loss.

J. T. Ratnanather, L. C. Wang, S. Bae, E. R. O'Neill, E. Sagi, and D. J. Tward, in Frontiers in Neurology.
From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data

Our analysis of tau tangles and amyloid plaques, using the windowed scattering transform to extract informative features from microscopy images. Presented at the MICCAI conference.

K. M. Stouffer, Z. Wang, E. Xu, K. Lee, P. Lee, M. I. Miller, and D. J. Tward, in International Workshop on Multimodal Learning for Clinical Decision Support.
Quantifying Patterns of Pathology: A Characterization of the 3D Spatial Distribution of Tau Tangles and Amyloid Plaques in Alzheimer's Disease Using Multi-Modal Image Registration with a Scattering Transform

A poster at the Alzheimer's association international conference desribing our analysis of tau tangles and amyloid plaques detected and reconstructed in 3D.

K. M. Stouffer, Z. Wang, E. Xu, K. S. Lee, P. Lee, S. Mori, J. C. Troncoso, A. Saito, M. S. Albert, M. I. Miller, and D. J. Tward, in 2021 Alzheimer's Association International Conference.
Identifying Structural Changes in the Brain Specific to Early Alzheimer's Disease

Invited talk describing image analysis techniques for studying early Alzheimer's disease.

D. J. Tward, in World Congress of Society for Brain Mapping and Therapeutics.
An Optical Flow Based Left-Invariant Metric for Natural Gradient Descent in Affine Image Registration

We developed a novel metric tensor for studying distances on the space of affine transformation matrices, and applied them to accelerate optimization in brain image alignment.

D. J. Tward, in Frontiers in Applied Mathematics and Statistics.
Entorhinal and transentorhinal atrophy in preclinical Alzheimer's disease

This work discusses atrophy in the medial temporal lobe during the progression of early Alzheimer's disease.

S. Kulason, E. Xu, D. J. Tward, M. S. Albert, L. Younes, and M. I. Miller, in Frontiers in Neuroscience.
Vestibular function and cortical and sub-cortical alterations in an aging population

This work discusses the association between visbular function (measured through cervical vestibular-evoked myogenic potential) and brain structures of interest using imaging data from the Baltimore Longitudinal Study of Aging.

A. Jacob, D. J. Tward, S. Resnick, P. F. Smith, C. Lopez, E. Rebello, E. X. Wei, J. T. Ratnanather, and Y. Agrawal, in Heliyon.
infinitesimal drift diffeomorphometry models for population shape analysis

This work discusses time dependent models of shape changes to study neurodegeneration.

B. C. Lee, D. J. Tward, Z. Hu, A. Trouve, and M. I. Miller, in Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops.
Coarse-to-Fine Hamiltonian Dynamics of Hierarchical Flows in Computational Anatomy

We developed optimal control formulations for parameterizing deformations and features described at multiple scales. This work is contributing to brain atlasing initatives for microscopy images.

M. I. Miller, D. J. Tward, and A. Trouve, in Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops.
3D printing hippocampi to depict atrophy-related Alzheimer's biomarkers

This work discusses the challenges of 3D printing hippocampi from annotated post mortem MRI. This work will help visualize subtle changes to complex anatomy during the disease.

F. Xu, E. Xu, J. Troncoso, M. Albert, D. J. Tward, and M. Miller, in Proceedings of the 2020 Summer Biomechanics, Bioengineering, and Biotransport Conference.

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