Early amygdala and erc atrophy linked to 3d reconstruction of rostral neurofibrillary tau tangle pathology in alzheimer's disease

Studying shape changes in the amygdala and relating them to tau tangles detected in digital pathology.

K. M. Stouffer, C. Chen, S. Kulason, E. Xu, M. P. Witter, C. Ceritoglu, M. S. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller, and {for the Alzheimer's Neuroimaging Initiative}, in NeuroImage: Clinical.
From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data

Our analysis of tau tangles and amyloid plaques, using the windowed scattering transform to extract informative features from microscopy images. Presented at the MICCAI conference.

K. M. Stouffer, Z. Wang, E. Xu, K. Lee, P. Lee, M. I. Miller, and D. J. Tward, in International Workshop on Multimodal Learning for Clinical Decision Support.
Quantifying Patterns of Pathology: A Characterization of the 3D Spatial Distribution of Tau Tangles and Amyloid Plaques in Alzheimer's Disease Using Multi-Modal Image Registration with a Scattering Transform

A poster at the Alzheimer's association international conference desribing our analysis of tau tangles and amyloid plaques detected and reconstructed in 3D.

K. M. Stouffer, Z. Wang, E. Xu, K. S. Lee, P. Lee, S. Mori, J. C. Troncoso, A. Saito, M. S. Albert, M. I. Miller, and D. J. Tward, in 2021 Alzheimer's Association International Conference.
Entorhinal and transentorhinal atrophy in preclinical Alzheimer's disease

This work discusses atrophy in the medial temporal lobe during the progression of early Alzheimer's disease.

S. Kulason, E. Xu, D. J. Tward, M. S. Albert, L. Younes, and M. I. Miller, in Frontiers in Neuroscience.
3D printing hippocampi to depict atrophy-related Alzheimer's biomarkers

This work discusses the challenges of 3D printing hippocampi from annotated post mortem MRI. This work will help visualize subtle changes to complex anatomy during the disease.

F. Xu, E. Xu, J. Troncoso, M. Albert, D. J. Tward, and M. Miller, in Proceedings of the 2020 Summer Biomechanics, Bioengineering, and Biotransport Conference.