Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

We developed a generative algorithm for registration of micron resolution serial section microscopy images to the Allen reference atlas.

D. J. Tward, X. Li, B. Huo, B. C. Lee, M. Miller, and P. P. Mitra, in bioRxiv.
Diffeomorphic Upsampling of Serially Acquired Sparse 2D Cross-Sections in Cardiac MRI

We design diffeomorphic techniques to estimate unobserved data between sparsely sampled slices in cardiac MRI.

B. C. Lee, D. J. Tward, J. Wei, D. Tipre, R. G. Weiss, M. I. Miller, and S. Ardekani, in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
Estimating diffeomorphic mappings between templates and noisy data: Variance bounds on the estimated canonical volume form

We derived the Cramer Rau bound for estimating volume changes from deformable image registration, which is a lower bound on the variance of an estimator. We demonstrated its implications for image registration performance in asymmetric methods versus symmetric methods, the former generally performing better.

D. J. Tward, P. P. Mitra, and M. I. Miller, in Quarterly of applied mathematics.
Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment
S. Kulason, D. J. Tward, T. Brown, C. S. Sicat, C. Liu, J. T. Ratnanather, L. Younes, A. Bakker, M. Gallagher, M. Albert, and others, in NeuroImage: Clinical.
P3-386: CORTICAL THICKNESS ATROPHY IN THE TRANSENTORHINAL CORTEX IN MILD COGNITIVE IMPAIRMENT
S. Kulason, D. J. Tward, C. S. Sicat, A. Bakker, M. Gallagher, M. S. Albert, and M. Miller, in Alzheimer's \& Dementia.
On variational solutions for whole brain serial-section histology using the computational anatomy random orbit model
B. C. Lee, D. J. Tward, P. P. Mitra, and M. I. Miller, in arXiv preprint arXiv:1802.03453.
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum
M. I. Miller, S. Arguill{\`e}re, D. J. Tward, and L. Younes, in Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
Cover Image, Volume 10, Issue 6
M. I. Miller, S. Arguill{\`e}re, D. J. Tward, and L. Younes, in Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
Quantification OF 3D tangle distribution in medial temporal lobe using multimodal image registration and convolutional neural networks
D. J. Tward, T. Brown, J. Patel, Y. Kageyama, S. Mori, J. C. Troncoso, and M. Miller, in Alzheimer's \& Dementia: The Journal of the Alzheimer's Association.
A community-developed open-source computational ecosystem for big neuro data

A series of open source and web accessible resources for studying neuroscience related data.

J. Vogelstein, E. Perlman, B. Falk, A. Baden, W. G. Roncal, V. Chandreshekhar, F. Collman, S. Seshamani, J. Patsolic, K. Lillaney, M. Kazhdan, R. J. Hider, D. Pryor, J. Matelsky, A. Crow, M. Write, S. Smith, T. Gion, P. Manavalan, B. Wester, M. Chevillet, E. Trautman, K. Khairy, E. Bridgeford, D. Kleissas, D. J. Tward, M. Miller, R. Vogelstein, K. Deisseroth, and R. Burns, in Nature methods.

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